Selective Internal Radiotherapy (SIRT) In the Management ofChemotherapy Refractory Cancers with Liver PredominantMetastasis: Results from a Tertiary Care Hospital in WesternAustralia
نویسندگان
چکیده
The technical details of this procedure are well described elsewhere [3]. 90Y-labelled microspheres are injected via a temporary hepatic artery catheter, placed percutaneously through the brachial or femoral artery. The dose and activity of 90Y-labelled microspheres is adjusted according to tumour volume, lung shunting fraction, and patient body surface area. Analysis of the distribution of microspheres following SIRT treatment shows that liver metastases derive their blood supply almost exclusively from the hepatic artery, whilst the portal circulation supplies the normal liver parenchyma [4]. This enables the delivery of high dose radiation, selectively to liver metastases.
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A 65 year old male with metastatic colorectal cancer (mCRC) in the liver was referred for selective internal radionuclide therapy (SIRT) following a history of extensive systemic chemotherapy. 90Y PET imaging was performed immediately after treatment and used to confirm lesion targeting and measure individual lesion absorbed doses. Lesion dosimetry was highly predictive of eventual response in ...
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